Efficacy of a Low-Dose Omeprazole-Based Triple-Therapy Regimen. Part 1

Objectives: To investigate the efficacies of two different
triple-therapy regimens (standard versus low doses), and the force of
cytochrome P450 enzyme (CYP) genetic pleomorphism on these efficacies,
in Asian patients undergoing Helicobacter pylori eradication intervention.
Methods:
All patients received 1 week of trio therapy.
Patients in set A (low-dose regimen) received omeprazole 40 mg/day +
amoxicillin 1500 mg/day + clarithromycin 800 mg/day; patients in
chemical group B (standard-dose regimen) received omeprazole 40 mg/day
+ amoxicillin 2000 mg/day + clarithromycin 1000 mg/day.
Results:
A totality of 225 patients (113 in abstract entity A and 112 in
chemical group B) were randomised to one of the two triple-therapy
regimens.
The eradication rates were 78.8% (89/113 patients; 95% CI 70.1, 85.9)
in abstraction A and 83.0% (93/112 patients; 95% CI 74.8, 89.5) in
abstract entity B.
Genetic chemical phenomenon of CYP2C19, a subject metabolic enzyme of
omeprazole, did not affect eradication rates, while susceptibility to
clarithromycin greatly affected the mortal of eradication.
The cumulative ulcer relapse rate at 24 weeks after endoscopically
documented ulcer healing (30 weeks after pass completion of the drug
regimen) was 8.3% for building block A and 12.5% for building block B
(log rank test: p = 0.6248).
However, equivalence of the cumulative relapse rate of 6.7% in patients
after successful H. pylori eradication with the relapse rate of 27.3% in those who failed H. pylori eradication revealed a significant departure in the remission-time delivery (log rank test: p = 0.0047).
This uncovering suggested the natural object of a kinship between H. pylori
eradication loser and ulcer relapse.
Both drug regimens were well tolerated.
Endoscopically proven flowing esophagitis developed in about 10% of
patients after eradication, but was not clinically significant.
Conclusions: One week of three-base hit therapy with a low-dose regimen provides adequate H. pylori eradication in Asian patients.
CYP genetic pleomorphism is of minimal clinical signification with both triple-therapy regimens.

This is a part of article Efficacy of a Low-Dose Omeprazole-Based Triple-Therapy Regimen. Part 1 Taken from "Buy Amoxil" Information Blog