H pylori Eradication With Sequential Therapy in Elderly Patients. Part 1

Interference: Helicobacter pylori eradication rates with triplet therapies are decreasing, and few data in elderly patients are available.
A 10-day sequential regimen succeeded in curing such H. pylori contagion in unselected patients.
Aim: To compare this sequential regimen and the volume unit triad therapy for H. pylori eradication in geriatric patients with peptic ulcer.
Methods: Coverall, 179 H. pylori-infected patients with peptic ulcer were enrolled (mean age: 69.5 years; piece of ground: 65-83).
Patients were randomized to 10-day sequential therapy (rabeprazole 20 mg b.d. plus amoxicillin
1 g b.d. for the get-go 5 days, followed by rabeprazole 20 mg,
clarithromycin 500 mg and tinidazole 500 mg, all b.d., for the
remaining 5 days) or flag 7-day set regimen (rabeprazole 20 mg,
clarithromycin 500 mg and amoxicillin 1 g, all b.d.). Helicobacter pylori condition was assessed by histology and rapid urease test at service line and 4-6 weeks after closing of idiom.
Results:
The sequential regimen achieved eradication rates significantly higher
in scrutiny with the metric regimen at both intention-to-treat (94% vs.
80%; P = 0.008) and per-protocol (97% vs. 83%; P =
0.006) analyses.
In both discussion groups, conformity to the therapy was high
(>95%), and the rate of mild side-effects was similarly low
(<12%).
At repeated speed endoscopy, peptic ulcer lesions were healed in 97%
patients, without a statistically significant departure between the
sequential regimen and the measure multiple therapy.
Conclusions:
In elderly patients with peptic ulcer disease, the 10-day sequential
handling regimen achieved significantly higher eradication rates in
likeness with value safety therapy.

This is a part of article H pylori Eradication With Sequential Therapy in Elderly Patients. Part 1 Taken from "Buy Amoxil" Information Blog